19th West Coast Protein Crystallography Workshop

Schedule WCPCW 2011

Program Schedule

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Sunday, March 20, 2011

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4:00pm Hotel Check-in
On your own for dinner tonight
 
6:00pm Registration Location: Foyer of Cypress Ballroom

6:30pm

Welcome Reception
Beer, wine and light snacks

Location: Foyer of Cypress Ballroom
7:30pm Opening comments
Tom Poulos
University of California, Irvine
Location: Cypress Ballroom
Keynote Speaker
7:45pm Harry F. Noller
University of California Santa Cruz
Ribosome Structure and Dynamics

Location: Cypress Ballroom

 

 

9:00pm Social
Beer, wine and snack
Location: Foyer of Cypress Ballroom
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Monday, March 21, 2011
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8:00am Continental Breakfast Location: Lower Terrace (weather permitting)

Session 1: METHODOLOGY
Discussion Leader- Alex McPherson, University of California, Irvine

Location: Cypress Ballroom

 

8:50am

Rick Bott, Genencor, "The role of temperature in visualizing flexible domains"

9:10am

Matthew Warkentin, LBL, "New results using temperature-dependent protein crystallography"

9:30am

James S. Fraser, UCSF, "Crystal freezing biases protein packing and obscures functional motions'

9:50am

James Holton, LBL, "The noise level of electron density maps"

10:10am

P. Therese Lang, UC Berkeley, "Revealing structural ensembles hidden in electron density"

 

10:30am Coffee Break Location: Foyer of Cypress Ballroom

Session 2: CRYSTAL COMPLEXES
Discussion Leader- Celia Goulding, University of California, Irvine

Location: Cypress Ballroom

 

10:50am

Zachary A. Bornholdt , Scripps, "Ebola virus: Some assembly required"

11:10am

Minglei Zhao, UCLA, "Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation"

11:30am

Heidi L. Schubert, Univ. Utah, "The nuclear Arp heterodimer bound to an HSA-domain"

11:50am

Ron Diskin, CalTech, "Crystal structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody"

12:10pm

Ryan VanderLinden, Univ. Utah, "The X-ray Crystal Structure of Rpn13:Uch37: Ubiquitin Complex and Implications for Uch37 Activation and Function"

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Monday March 21, 2011
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12:30pm Lunch Location: Upper Plaza (weather permitting)
1:00pm Free time  
6:00pm Dinner Location: Dolphins Room (located right off the Upper Plaza)

Session 3: MEMBRANE PROTEINS
Discussion Leader: Hartmut "Hudel" Luecke, University California, Irvine

Location: Cypress Ballroom

 

7:30pm

Eric Johnson, CalTech, "Relating conformational changes the ATPase active state in the E. Coli high-affinity methionine ABC transporter MetNI"

7:50pm

Theresa Tiefenbrunn, Scripps, "The 1.8 Å Resolution Structure of Cytochrome ba3 Oxidase Obtained From the Lipidic Cubic Phase"

8:10pm

Troy Walton, CalTech, "Exploring the structural role of the MscL cytoplasmic bundle"

8:30pm

James Holton, LBL, “X-ray lasers: no longer science fiction”

 

8:50pm Social and Poster Session Location: Monterey Bay Room
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Tuesday, March 22, 2011
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8:00am Continental Breakfast Location: Lower Terrace (weather permitting)

Session 4: METHODOLOGY
Discussion Leader: Howard Einspahr, IUCr Journals

Location: Cypress Ballroom

 

8:50am

James Holton, LBL, "What is "good enough"? Predicting the success or failure of structure solution from first principles"

9:10am

Puneet Souda, UCLA, "High Resolution Mass Spectrometry to Profile Integral Membrane Proteins And Their Post Translational Modifications"

9:30am

Tzanko Doukov, SSRL, "Crystallographic and Single Crystal Spectral Analysis of the Peroxidase Ferryl Intermediate"

9:50am

Allen M. Orville, BNL, "Removing the Mystery from Mystery Density in X-ray Crystallography with Single-Crystal Spectroscopy"

10:10am

Rachna Ujwal, UCLA, "High-throughput crystallization of membrane proteins using lipidic bicelle method"

 

10:30am Coffee Break Location: Foyer of Cypress Ballroom

Session 5: MECHANISMS
Discussion Leader: Heidi Schubert, University of Utah

Location: Cypress Ballroom

 

10:50am

Eric Montemayor, Univ. Texas Health Sci. Ctr. San Antonio, "Structures of the RNA Lariat Debranching Enzyme Dbr"

11:10am

John C. Williams, City of Hope, "The role of valency on the regulation of protein function: Structural, biochemical and in vivo studies of the dynein regulatory subunits"

11:30am

Rick Cooley, Oregon State, "Symerythrin: an unorthodox story of protein evolution from a simple peptide to the most powerful oxidizing enzymes in biology"

11:50am

Elizabeth J. Goldsmith, Uni. Texas. Southwest. Med. Ctr. Dallas, "The third conformer of p38α observed in solution and in phosphorylated p38α"

12:10am

Camden M. Driggers, Oregon State, "Structural Studies Toward Understanding the Mechanism of Mammalian Cysteine Dioxygenase"

 

12:30pm Lunch Location: Upper Plaza (weather permitting)
1:00pm Free time  
6:30pm Dinner Location: Dolphins Room (located right off the Upper Plaza)

Session 6: METHODOLOGY 3
Discussion Leader: Allen Orville, Brookhaven National Laboratory

Location: Cypress Ballroom

 

7:30pm

Jeffrey J. Headd, LBL, "Knowledge-based restraints in phenix.refine for improved macromolecular refinement at low resolution"

7:50pm

Dale Tronrud, Oregon State, "Using a Conformationally-Dependent Stereochemical Library Improves Crystallographic Refinement of Proteins"

8:10pm

Alex McPherson, UCI, "1.45 Å Resolution Refinement of STMV"

8:30pm

Lida K. Gifford, LBL, "PSI SBKB Technology Portal: A Web Resource for Structural Biologists"

 

9:00pm Social and Posters  
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Wednesday, March 23, 2011

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Session 7: CRYSTALLOGRAPHY AND MEDICINE
Discussion Leader: Sheryl Tsai, University of California, Irvine

Location: Cypress Ballroom

 

8:50am

Hay Dvir, La Jolla Institute for Allergy & Immunology, "Structure of the LDL receptor tail in complex with ARH: Implications to Hypercholesterolemia"

9:10am

Argentina Becker, Univ. Texas Health Sci. Ctr. San Antonio, "The Structure of CARDS Toxin from Mycoplasma pneumonia"

9:30am

Enrico Girardi, La Jolla Institute for Allergy & Immunology, "Recognition of microbial antigens by the invariant NKT TCR

9:50am

Debasish Chattopadhyay, Univ. Alabama, Birmingham, "Trypanosoma cruzi Dihydrofolate Reductase Thymidylate Synthase: a potential target for drugs against Chagas' disease"

10:10am

Ahmad Galaleldeen, Univ. Texas Health Sci. Ctr. San Antonio, "Structure of the Chlamydial Effector Protein Pgp3"


10:30am Coffee Break Location: Foyer of Cypress Ballroom

Session 8: NEW STRUCTURES AND MECHANISM
Discussion Leader: John Williams, Brookhaven National Laboratory

Location: Cypress Ballroom

 

10:50am

Eva Rose M. Balog, UCSC, "The structure of a monomeric mutant Cks protein reveals multiple roles for a conserved hinge-region proline"

11:10am

Seth M. McDonald, UCSC, "Structure and Biochemistry of the Yeast Transcription Factors Spt6 and Spn1/Iws1"

11:30am

Victoria S. Jasion, UCI, "The Crystal Structure of Leishmania major Peroxidase and Characterization of the Compound I Tryptophan Radical"

11:50pm

Sheryl Tsai, UCI, "Structural Basis of Polyketide Cyclization"

12:10pm

Arthur Laganowsky, UCLA, "Revealing the structural mechanisms of alpha crystallins in eye lens transparency"

 

12:30pm

Poster/oral presentation awards, next WCPCW organizer, farewell
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